PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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2-(3-(Aminomethyl)phenyl)acetic acid
0 ImagesCat. No.: HY-W340290CAS No.: 113520-43-7Synonyms: 3-Aminomethyl-phenylacetic acid
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Deca-1,9-diyne
0 ImagesSynonyms: 1,9-Decadiyne
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4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-4-oxobutanoic acid
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Tert-butyl 4-(4-(hydroxymethyl)benzyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W274524CAS No.: 622381-67-3
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HO-PEG3-(CH2)6-Cl
0 ImagesCat. No.: HY-W613607CAS No.: 1355955-95-1
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Ph-PEG5-Br
0 ImagesCat. No.: HY-W594797CAS No.: 675606-48-1
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(((6-Bromohexyl)oxy)methyl)benzene
0 ImagesCat. No.: HY-W011656CAS No.: 54247-27-7
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Tert-butyl 3-(((benzyloxy)carbonyl)amino)propanoate
0 ImagesCat. No.: HY-W273180CAS No.: 18605-26-0
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Phenylmethyl N-(5-bromopentyl)carbamate
0 ImagesCat. No.: HY-W594785CAS No.: 161533-09-1
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N-(m-PEG4)-N'-(biotin-PEG3)-Cy5
0 ImagesCat. No.: HY-141070CAS No.: 2107273-68-5
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tert-Butyl 4-(piperidin-3-ylmethyl)piperazine-1-carboxylate dihydrochloride
0 ImagesCat. No.: HY-W377732CAS No.: 1211498-87-1
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N,N'-(Pentane-1,5-diyl)bis(2-chloroacetamide)
0 ImagesCat. No.: HY-W175189CAS No.: 33619-33-9
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2-Bromo-N-(but-3-yn-1-yl)acetamide
0 ImagesCat. No.: HY-W172608CAS No.: 1204333-33-4
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NH2-C6-O-C5-O-C4-COOH
0 ImagesCat. No.: HY-W1130286
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Cbz-NH-PEG3-tosyl
0 ImagesCat. No.: HY-W580126CAS No.: 2098983-15-2
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(R)-tert-Butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate
0 ImagesCat. No.: HY-W069358CAS No.: 1420537-04-7
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Methyl 6-aminospiro[3.3]heptane-2-carboxylate hydrochloride
![Methyl 6-aminospiro[3.3]heptane-2-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w057096.gif "Click to View Methyl 6-aminospiro[3.3]heptane-2-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W057096CAS No.: 1808249-67-3
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(4-Oxo-4H-quinazolin-3-yl)-acetic acid
0 ImagesCat. No.: HY-W030545CAS No.: 14663-53-7
